In the spring of 1999, Luke moved to Nashville to establish himself as a full time musician. He spent his early years in Tennessee playing fiddle in Ricky Skaggs’ band, Kentucky Thunder, which earned him his first Grammy Award.

Following the Skaggs stint, he became a member of the John Cowan Band. More recently Luke has performed and/or recorded with Brandi Carlile, Jim Lauderdale, Darrell Scott, Alison Krauss, Jerry Douglas, Sam Bush, Edgar Meyer, Bela Fleck, Bryan Sutton, Kevin Costner & Modern West, Russ Barenberg Trio, Shawn Colvin, Tony Rice, Chris Thile, Peter Rowan, Patty Griffin, Glen Phillips, Rodney Crowell, and Earl Scruggs, to name a few. Luke was also a perennial instructor at Mark O’Connor’s fiddle camps in his early Nashville years.

In addition to violin, Luke plays guitar and mandolin, and sings and writes songs.

With his long-time friend Casey Driessen, Luke founded the band Wisechild, which toured briefly with John Mayer and Counting Crows. He also had a band collaboration, W.P.A. (Works Progress Administration), which included members Sean Watkins (Nickel Creek, Fiction Family), Glen Phillips (Toad The Wet Sprocket), Sara Watkins (Nickel Creek, I’m With Her), Benmont Tench (Tom Petty and the Heartbreakers), Pete Thomas (Elvis Costello and the Imposters, The Attractions, Los Lobos), Greg Leisz (Joni Mitchell, Wilco, Sheryl Crow, Beck), and Davey Faragher (Elvis Costello and the Imposters, Cracker).

In 2009, Luke released a solo EP featuring Jerry Douglas, Sam Bush, Bela Fleck, Aoife O’Donovan and more.

That same year, Lyle Lovett asked Luke to join his Large Band, with whom he toured full time until 2023.